RFdiffusion3 designs proteins atom by atom and works in lab experiments
Overview
A team from the University of Washington, Oxford and NVIDIA published RFdiffusion3 in Science, a generative AI system that designs proteins and nucleic acids by setting the 3D coordinates of individual atoms.
The system represents each amino acid with up to 14 atoms. On 41 enzyme active sites, IT Home reports, it outperformed its predecessor RFdiffusion2 in 37 tests and generates structures about ten times faster.
Two enzymes designed by RFdiffusion3, an organophosphate-degrading enzyme and a peptide cleavage enzyme, completed their intended chemical reactions in real experiments. RFdiffusion3 was developed with reference to the network architecture of AlphaFold3, another protein structure prediction program.
Written by AI from the articles below · updated Oct 18, 8:13 PM ET
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- IThome · AINewsRFdiffusion3 designs proteins atom by atom and works in lab experiments
AIA team from the University of Washington, Oxford and NVIDIA published RFdiffusion3 in Science, a generative AI system that designs proteins and nucleic acids by modeling individual atoms. It represents each amino acid with up to 14 atoms and sets their 3D coordinates directly. On 41 enzyme active sites, it outperformed RFdiffusion2 in 37 tests and generates structures about ten times faster. Two enzymes it designed, a organophosphate-degrading enzyme and a peptide cleavage enzyme, completed their intended chemical reactions in real experiments.
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