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View original post on X: Lewis Tunstall
Published
25/100

Frontier models struggle to classify genetic variants as harmless or harmful

AILewis Tunstall says three frontier models were tested on classifying 1,000 genetic variants as harmless or harmful. GPT-6.1 Sol returned bare labels with its reasoning encrypted, Gemini 4 Argon refused more than 50% of prompts, and Opus 5.5 ran out of tokens on about 20%.
Lewis TunstallVerified on X
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Part of a thread · earlier post

To give you a taste of what it looks like when distillation doesn't work, we asked three frontier models to classify 1,000 genetic variants: harmless or harmful?

GPT-6.1 Sol answered every one with a bare label, its reasoning encrypted. Gemini 4 Argon refused >50% of the time, while Opus 5.5 ran out of tokens on ~20% of prompts.

Open weight models were also terrible at these DNA understanding tasks, barely better than random.

tl;dr almost nothing to learn from 🫠

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Lewis Tunstall · x.comPublished

Original title: To give you a taste of what it looks like when distillation doesn't work, we asked three frontier models to classify 1,000 genetic varian...