Why AI still struggles to decode the genome's regulatory complexity

Genomic foundation models such as Evo 2, Genos, and Google DeepMind's AlphaGenome are trained on large genomic datasets to predict how DNA sequence differences affect biological processes.

The article argues that the genome's gene regulation is too complex for such black-box models to fully explain. Researchers have only scratched the surface of the three-dimensional knots that influence genome function.