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Claude designs protein binders against scorpion neurotoxins in an agent-run campaign

AIAnthropic's Claude, running as an agent inside its Claude Science setup, ran a protein-design campaign against scorpion neurotoxins on its own. It chose 180 of 318,484 generated molecules for synthesis, and 17 of 211 tested designs bound their toxins in tests at Adaptyv Bio and Twist Bioscience.
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Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.

Claude, running as an agent inside Anthropic’s Claude Science setup, ran the whole protein-design campaign itself:

it picked which patch of each scorpion toxin to attack, drove 12 protein-design programs, set its own scoring cutoffs, and chose 180 molecules out of the 318,484 it generated for physical synthesis, and 17 of the 211 designs tested bound their toxin at Adaptyv Bio and Twist Bioscience.

Citrini Research, a finance firm with no lab and no protein expertise, asked for this work, and Claude designed proteins that two labs confirmed latch onto scorpion venom toxins.

Scorpion stings kill more than 3,250 people a year, so the prize is real, if this method works. However, Anthropic is not calling this an antivenom, because the test that would justify the word has not been run yet.

Anthropic@AnthropicAI
New on our Science Blog: designing protein binders against scorpion neurotoxins. Scorpions sting about 1.2m people every year, and antivenoms are often costly or in short supply. Claude has made an early step toward finding new treatments. https://www.anthropic.com/research/claude-scorpion-toxin-binder-design
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Rohan Paul · x.comPublished

Original title: Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.