# Demeta Bio's oral LDHA inhibitor MP-5342 starves overactive immune cells of energy

> Original title: 在代谢酶网络里，默达生物找到了一个让坏细胞「吃不饱饭」的开关

- Source: Leiphone
- Published: 2026-10-30T09:51:00.000Z
- Bad Influence: https://badinfluence.news/items/xxuodt5aqx1h9rrb4aoium03v
- Original: https://www.leiphone.com/category/aihealth/zzOQHx9piL86TXHJ.html

## Summary

Demeta Bio says its oral small-molecule LDHA inhibitor MP-5342, co-developed with XtalPi, targets glycolysis in overactive immune cells to restore immune balance without broad suppression. The company reports a safety window above 600 times, far beyond the typical threshold of 40 times, and plans to enter Phase I trials in healthy volunteers in 2027 and Phase IIa patient trials in 2028.