# Google DeepMind releases AlphaGenome 2 to predict cell-type-specific DNA variant effects

> Original title: AlphaGenome 2: Deciphering how cells read DNA to better understand disease

- Source: Google DeepMind
- Published: 2026-11-11T15:00:15.000Z
- Bad Influence: https://badinfluence.news/items/nd9pzjolu5njvzucr24ymrkdm
- Original: https://deepmind.google/blog/alphagenome-2-deciphering-how-cells-read-dna-to-better-understand-disease/

## Summary

Google DeepMind announces AlphaGenome 2, a conditional model that predicts how DNA variants affect specific human cell types. It identifies nearly twice as many causal variants as the original model in the TenK10K immune-cell dataset, 30% versus 16%. The model is available today for non-commercial research via the AlphaGenome API and in private preview for commercial research, and it is intended for research use only, not clinical or diagnostic purposes.

## Why it matters

The post explains how conditioning on cell type changes variant predictions, with a concrete IBD example, useful for judging how such models fit genetics research.