#Paper/Research

AIAnthropic researchers used Claude Science to compute the nine-loop six-particle amplitude in planar N=4 super Yang-Mills, a toy-model result that physicist Lance Dixon checked. The work reportedly cost roughly one or two thousand dollars, with about $100 of compute for the bootstrap calculation, and a similar result was reached by Song He's group.

Why it matters: The guest post shows a frontier physics calculation done with modest compute, which helps readers gauge what current AI can handle in research and what it still cannot.

AIAnthropic is introducing a molecular biology research group and lab to test whether Claude can help scientists find unusual proteins. Claude combs through large DNA datasets, flags uncharacterized proteins, and passes its most promising ideas to scientists, who test them at the bench. In one early program, Claude discovered a novel enzyme system with CRISPR-like repeats.

Why it matters: The source shows Claude being used in a wet-lab workflow, from scanning DNA datasets to flagging proteins for scientists to test at the bench.

AICognition's Devin agent, directed by Eric Lu, factored the 260-digit RSA-260 number using a new GPU implementation of the general number field sieve built on CADO-NFS. The author estimates the run cost about 13.5 GPU-years, roughly $400k at market prices, and projects RSA-1024 factoring at around $30M, while RSA-2048 is not meaningfully affected.

Why it matters: The source gives a full cost breakdown and scaling estimates for RSA factoring on GPUs, showing how far the cost of breaking RSA-1024 has fallen.

AIOpenAI reports that its automated system found accidental chain-of-thought grading in RL runs for several released models, including GPT-5.4 Thinking and GPT-5.4 mini. Its analysis found no clear reduction in CoT monitorability, though the company says subtler effects cannot be ruled out. OpenAI says it still avoids grading CoTs during RL and has fixed the affected reward pathways.

Why it matters: The post shows how accidental chain-of-thought grading was detected and tested, giving a concrete method for checking monitorability risks in RL training.